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Sina Y. Rabbany

Dean, School of Engineering and Applied Science, Professor of Engineering


Degrees

PHD, 1991, University of Pennsylvania; MSE, 1986, University of Pennsylvania; BSE, 1985, University of Pennsylvania


Bio

Research:

Dr. Rabbany is currently doing research in the field of cellular and tissue engineering as applied to the vascular system. One of the major obstacles in engineering vascularized tissue is induction of endothelial vessel networks. To this end, his research applies engineering principles to the advancements being made in the differentiation of embryonic stem (ES) cells toward engineering vascularized tissue. The focus of the research is to expand pure populations of stem cells in vitro, and influence their cell fate decisions to direct differentiation into vascular cells including functional transplantable endothelial (EC) and smooth muscle (SM) cells. Understanding the mechanistic basis of ES cell differentiation into functional ECs is critical to various aspects of tissue engineering and regenerative medicine. In addition, tissue explants generated by these vascular cells can be introduced in vivo to restore function by augmenting vessel growth, in the ischemic myocardium or limbs of patients after heart attacks or diabetic vascular diseases. The projects range from elucidating the role of physical forces such as cyclic stretch, simulated microgravity, and shear stress on vascular cells and engineering of vascularized constructs. In the past, he has done research in the areas of cardiovascular Mechanics and Biosensors, and cell & receptor biomechanics.

Honors & Awards:

Presidential Research Award, Hofstra University (1992-2001)
Citation, Explorers Club, New York Chapter (2000)
American Society for Engineering Education Summer Faculty Fellowship (1991-1999)
Research and Development Grant, Hofstra University (1991-2001)
Editor, Proceedings of the Biomathematics and Bioengineering 1993 Conference (1993)
Citation, American Society of Mechanical Engineers, Long Island Chapter (1993)
Office of Naval Technology Postdoctoral Fellowship Review Panel (1992)
Sagawa Young Investigators Award, Cardiovascular Systems Dynamics Society (1992)
Award of Appreciation, Premedical Honor Society, Hofstra University Chapter (1992)
Release Time, Center for Scholarly Research and Academic Excellence, Hofstra University (1990-1993)
Postdoctoral Fellowship, Georgetown University/Naval Research Laboratory (1990)
Training Grant, University of Pennsylvania (1987-1988)
National Institute of Health Research Fellowship (1984-1986)
Founder Scholarship for Outstanding Achievement in Biomedical Engineering Studies (1986)
Mortar Board Senior Honor Society, University of Pennsylvania (1985)
DEAN'S List, University of Pennsylvania (1983)

Current Funding:

Office of Naval Research -- Innovative Methodologies in immunoassay Design (1996-2002)
Faculty Development & Research Grant -- Cardiac Muscle Mechanics (1998-1999)
Presidential Research Award -- Transport Mechanisms Across Muscle cell Membrane (1999)

Areas of Specialization:

My research involves the application of both experimental and theoretical methods to study complex biological processes and is focused on the areas of Biosensors, Cardiovascular Dynamics, and Cellular Biomechanics.

Industrial Experience:

Design and development of a parallel-plate flow chamber, Cornell Medical College (2001)
Micro-fabricated an immunosensor for the detection of aflatoxin, JHU/APL (1996)
Development and Testing of a displacement Flow Immunoassay, NRL (1990-1996)

Academic Interests:

Teach courses in both Engineering and Biology Departments. Responsible for general engineering courses, developing new bioengineering courses, physiology laboratory and incorporating computer-based experiments in the laboratory. Coordinate the bioengineering specialization and integrate it within the Engineering Science Program. Developed the bioengineering research laboratory. Design and supervise clinically oriented research projects for both undergraduates and graduate students.

Courses Taught:

ENGG 9A: Introduction to Engineering
ENGG 181: Introduction to Bioengineering
ENGG 166B: Medical Instrumentation
ENGG 176: Network Analysis
ENGG 179: Control Systems Engineering
ENGG 182: Biomechanics and Biomaterials
ENGG 183: Special Topics in Bioengineering
BIO 144: Animal Physiology Laboratory

Supervised Student Projects:

Mechano-Chemical Alteration of Endothelial Cell Morphology and Function
Design and Construction of a conflate Viscometer
Design of a Proximal Radial Head Prosthesis
Artificial Urinary Sphincters
Membrane Displacement Immunoassay for Explosives
Kinetics of Immobilized Antibody-Antigen Interactions
Real Time, Body Surface EKG Signal Mapping and Recording
Pump/Controller Unit for a Left Ventricular Assist Device
Finite Element Analysis of Cardiac Muscle Cells
Cellular Volume Responses to Hypoosmotic Stresses
Cardiac Muscle Properties during Cardiac Ablation
Finite Element Analysis of Cardiac Muscle Cells
Frequency Analysis of Electrocardiograms
Selective Hearing: Construction of a Vocal Stripper
Piezoelectric Film Transducer for Heart Rate Monitoring
An Assay for Caffeine Detection
Diffusion Considerations in Design of Immunoassays
Design of Toys for Children with Cerebral Palsy
Viscoelastic Considerations in Muscle Mechanics

Publications:

Professional & Technical Memberships:

Biomedical Engineering Society (BMES) 1985-Present
Biophysical Society 1998-Present
Cardiovascular System Dynamic Society (CSDS) 1984-Present
Council on Undergraduate Research (CUR) 1994-Present
The Institute of Electrical and Electronics Engineers (IEEE) 1985-Present

Outside Interests:

Biking, Gardening, Reading, Book Collecting, Classical Music.


Teaching Interests

bioengineering, biomechanics, cell and tissue engineering, stem cell biology

Research Interests

Dr. Rabbany is currently doing research in the field of cellular and tissue engineering as applied to the vascular system. One of the major obstacles in engineering vascularized tissue is induction of endothelial vessel networks. To this end, his research applies engineering principles to the advancements being made in the differentiation of embryonic stem (ES) cells toward engineering vascularized tissue. The focus of the research is to expand pure populations of stem cells in vitro, and influence their cell fate decisions to direct differentiation into vascular cells including functional transplantable endothelial (EC) and smooth muscle (SM) cells. Understanding the mechanistic basis of ES cell differentiation into functional ECs is critical to various aspects of tissue engineering and regenerative medicine. In addition, tissue explants generated by these vascular cells can be introduced in vivo to restore function by augmenting vessel growth, in the ischemic myocardium or limbs of patients after heart attacks or diabetic vascular diseases. The projects range from elucidating the role of physical forces such as cyclic stretch, simulated microgravity, and shear stress on vascular cells and engineering of vascularized constructs. In the past, he has done research in the areas of cardiovascular Mechanics and Biosensors, and cell & receptor biomechanics.

Recent Courses Taught

Course Title Level
ENGG 143G INDEPENDENT ENGG DESIGN B Undergraduate
Photo of Sina Rabbany

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