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Richard W. Denton

Adjunct Assistant Professor of Chemistry


Degrees

PHD, 2007, CUNY Gr Sch & Univ Cnt; MPHIL, 1999, Univ West Indies; BS, 1996, Univ West Indies


Research Interests

Synthesis of IsoxazoleI inhibitors of the Influenza Virus

Influenza, or the flu is a contagious respiratory infection caused by influenza viruses.  It is reported annually to affect a large percentage of the US population.  Clinically, influenza presents itself with high fever, chills, sore throat, headache, runny or stuffy nose, weakness, muscle pain and sometimes diarrhea or vomiting in children.  There can be hospitalizations of up to 200,000 people and between 3,000 and 49,000 deaths during a season.i  The virus ability to mutate frequently makes it increasingly resistant to existing vaccines and antiviral drugs.  As a result of this, there is ongoing research to prepare new drugs to combat this virus.   The drug, Laninamivir (1) has long term inhibitory effect against the neuraminidase (NA) enzyme of influenza A and B.ii  This enzyme is needed by the virus to prolong its life in the host cell.  Hence blocking the action of NA is an effective way to treat influenza.  The key interactions between compound 1 and the NA of the virus are known from the X-ray crystal structure of the stabilized protein-laninamivir complex. 
My research focuses on the synthesis of isoxazole-based inhibitors of the neuramidase enzymes for the influenza virus.  These isoxazole scaffolds possess the key moieties identified in laninamivir and may prove to be significant mimetics of the drug. 


i Barik: New treatments for influenza. BMC Medicine. 2012, 10:104

ii Meepraserta, A.; Khuntaweeb, W.; Kamlungsuaa, K.; Nunthabootc, N, Rungrotmongkold, T.; Hannongbuaa, S. Binding pattern of the long acting neuraminidase inhibitor laninamivir towards influenza A subtypes H5N1 and pandemic H1N1. Journal of Molecular Graphics and Modelling. 2012, 38, 148–154


Recent Courses Taught

Course Title Level
CHEM 002A INTRO TO CHEMISTRY Undergraduate
CHEM 003A (NS) GENERAL CHEMISTRY I Undergraduate
CHEM 004A (NS) GENERAL CHEMISTRY II Undergraduate
CHEM 140 FOUNDTNS OF INORGANIC CHEM LAB Undergraduate
CHEM 152 UNDERGRAD RESEARCH 2 Undergraduate
Photo of Richard Denton

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